What is Knee
Osteoarthritis?

Osteoarthritis is a condition that involves the wearing down of cartilage (the protective covering on the ends of your bones) and loss of cushioning fluid in the joint19.

Frequently Asked Questions 20,21 

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What is an HA Injection?

If you suffer from pain associated with osteoarthritis of the knee, unresponsive to non-pharmacologic therapy and simple analgesics, your doctor may suggest Hyaluronic Acid injections, also called viscosupplemntation therapy. HA injections are used in a non-surgical treatment for knee pain that helps supplement the viscous properties of the fluid in your knee joint. Our multi-regimen line of Hyaluronic Acid injections are approved for patients who have not adequately responded or have failed to find sufficient relief from simple analgesics, exercise or physical therapy.

How does Hyaluronic Acid (HA) for knee pain work?

The fluid (synovial fluid) in your knee helps to lubricate and cushion the joint during movement. The major component in the synovial fluid is hyaluronic acid, the equivalent active component of our HA for knee pain products. One of the early effects of Osteoarthritis (OA) is to break down this fluid, making it less effective. Clinical research shows Hyaluronic Acid for the knee helps restore the synovial fluid to a more healthy state, thereby reducing OA joint pain in patients who are unresponsive to non-pharmacologic therapy and simple analgesics.

How is the HA administered?

TriVisc and GenVisc are administered by intra-articular injection. Intra-articular means your healthcare professional will insert a needle into the space in your knee joint that contains fluid used for lubrication and cushioning. 

How many Hyaluronic Acid injections should I receive?

Only you and your doctor can decide how many HA injections you should receive. 

GenVisc850

GenVisc 850 is supported by the largest and longest duration double blinded clinical study of hyaluronic acid for knee osteoarthritis, in patients unresponsive to non-pharmacologic therapy and simple analgesics. Clinical studies demonstrated that five hyaluronic acid injections one week apart provide optimal pain relief from knee osteoarthritis, in patients unresponsive to non-pharmacologic therapy and simple analgesics. Some patients have derived benefits following the third injection. The effectiveness of less than three hyaluronic acid injections has not been evaluated. You should discuss this with your doctor. Completion of the full injection treatment course is recommended to achieve the greatest therapeutic benefit.

Prescribing Information

TriVisc

Clinical investigations with TriVisc have demonstrated that three hyaluronic acid injections one week apart provide optimal pain relief in patients unresponsive to non-pharmacologic therapy and simple analgesics. The effectiveness of less than three hyaluronic acid injections has not been evaluated. You should discuss this with your doctor. Completion of the full injection treatment course is recommended to achieve the greatest therapeutic benefit.

Prescribing Information

When can I expect pain relief?

Each patient’s response to hyaluronic acid injections may vary depending on the severity of your knee osteoarthritis, degree of pain, and pre-existing medical conditions. In some patients, successful treatment may reduce pain within the first week after treatment begins. However, based upon clinical trials, most patients who are unresponsive to non-pharmacologic therapy and simple analgesics,  experience pain relief after their third HA injection given at weekly intervals.

You and your healthcare provider will decide upon the best course of treatment. Injection of subcutaneous lidocaine or similar local anesthetic may be recommended by your healthcare provider prior to receiving hyaluronic acid injections .

How long do Hyaluronic Acid injections last?

While each patient reacts differently to hyaluronic acid injections, the benefits can last months. In clinical studies many patients experience at least 3 to 6 months or more pain relief from OA knee joint pain. There are reports in the literature of pain relief beyond 6 months.

How safe are your Hyaluronic Acid injection products?

GenVisc 850 is approved and has been determined to be safe and effective. It has also been used throughout the world over the past 20 years. Now approved in 64 countries, with over 45 million syringes distributed worldwide.

TriVisc was approved for use in the United States in 2017. TriVisc has demonstrated a very favorable safety profile, with over 35 million doses administered worldwide since its first approval and has been studied in over 30 clinical trials for use in relieving osteoarthritis knee pain.

What should I do after my treatments?

It is recommended that you avoid strenuous activities such as jogging, tennis, and heavy lifting for at least 48 hours after receiving an injection. Your healthcare provider will advise you about the level of activity that is right for you. Most patients are able to maintain their normal, daily activities soon after receiving treatment for knee pain.

Can I take other medications in combination with Hyaluronic Acid injections?

Avoid both GenVisc850 and TriVisc if you have a known hypersensitivity (allergy) to HA products such as rash, itching, hives, flushing, swelling of the face, tongue or throat, and/or difficulty breathing. Hyaluronic Acid injections should not be administered in people with infections or skin diseases in the area of the injection sit. Speak to you doctor about the various treatment options for knee pain.

Link to Full Prescribing Information for GenVisc850

Link to Full Prescribing Information for TriVisc

Are there any reasons why I should not receive Hyaluronic Acid injections?

Avoid both GenVisc850 and TriVisc if you have a known hypersensitivity (allergy) to HA products such as rash, itching, hives, flushing, swelling of the face, tongue or throat, and/or difficulty breathing. Hyaluronic Acid injections should not be administered in people with infections or skin diseases in the area of the injection sit. Speak to you doctor about the various treatment options for knee pain.

What are the possible side effects?

Some side effects may occur during the use of HA with symptoms such as knee pain, inflammation, reddening, swelling appearing at the injection site and/or joint pain. Tell your healthcare provider if you experience any side effects after treatment of GenVisc 850 or TriVisc.

How much do HA injections cost? Will my insurance cover HA injections?

Most insurance carriers and Medicare cover viscosupplementation therapy. The process of obtaining reimbursement varies from plan to plan so talk with your doctor’s office and your insurance provider before you begin treatment for knee pain to find out if our HA products are covered. 

If your plan does not cover our line of Hyaluronic Acid Injections, or you choose not to use insurance to pay for the treatment, TriVisc is available, with a prescription, for purchase directly from our pharmacy partner network at a significant cost savings.

For more on the TriVisc Direct Purchase program visit here.

You can also download the form to give to your physician to fill out.

How do I know if Hyaluronic Acid injections are right for me?

Your healthcare provider is the best person to advise you on any course of treatment. Both Genvisc850 and TriVisc are approved for the non-surgical treatment of OA knee pain in patients who do not get enough relief from simple over the counter pain medication or from exercise and physical therapy.

For more Information, please ask your healthcare provider or refer to:

Link to Full Prescribing Information for GenVisc850

Link to Full Prescribing Information for TriVisc